UCL School of Life and Medical Sciences brings together four faculties to create one of the largest and most prestigious aggregations of academics in biomedical, life and population health sciences. The School has a global reputation for teaching informed by cutting-edge research. The School also coordinates nine research domains, which draw together research activity across the faculties and beyond.
Clinical Pharmacology & Therapeutics was created in 2013 to foster one of the main research domains, namely, Experimental Medicine, which brings together researchers and clinicians from all disciplines across UCL and UCL Partners. Our aim is to foster innovation in medical diagnosis and to develop new therapeutic approaches. A translational research programme is envisaged in which methodologies to address each of the four areas underpinning attrition in drug development will be investigated: 1) from in vitro to in vivo; 2) from health to disease; 3) from short-term to long-term and 4) from randomised controlled trials to real-life conditions.
UCL will be leading the GABA-3 bridging and modelling study for the extrapolation of data in children 3 months-3 years (WP9). In addition to this activity, UCL will coordinate the pharmacokinetics assessments conducted in GABA-1 (WP7) and GABA-2 (WP8) trials and will participate to the other commonly shared activities embedded in the project.
Oscar Della Pasqua, MD, PhD: Senior Director Clinical Pharmacology & Discovery Medicine at GlaxoSmithKline, United Kingdom and Professor Chair Clinical Pharmacology & Therapeutics at the School of Life and Medical Sciences, University College London. In addition to his extensive experience in early and late clinical development, he leads a research group focused on biomarkers, disease modelling and clinical trial design methodology, which has resulted in more than 75 publications in clinical and scientific journals. Dr. Della Pasqua chairs the Medicines for Children Advisory Network (MCAN), an internal expert panel at GlaxoSmithKline and is also a member of the Global Research in Paediatrics Network of Excellence, where he coordinates the efforts on novel methodologies for the evaluation of paediatric efficacy and safety data. Since 2008 he holds an affiliated lecturer position at the University of Cambridge where he contributes the Clinical Pharmacology module in Translational Medicine and Therapeutics (TMAT).
Andreas Matthios, MSc: Pharmacist specialised in Clinical Pharmacy and Pharmacotherapy at the University of Patras, Greece. In addition to internship experience during his MSc training, he has participated in a Erasmus placement programme in pharmacokinetic and pharmacodynamic modelling and simulation at the University of Leiden. He has recently joined UCL as a PhD student in Clinical Pharmacology & Therapeutics.